ResearchCheck out some of the research our team has done in the past

Effects of Melatonin on human sleep and other conditions

Our studies were the first to establish the sleep promoting effects of the low doses of melatonin. These doses induce circulating melatonin levels comparable to those that people normally have at night. Similar doses were also found to effectively shift the circadian Clocks. The results of this research instructs our strategy in using melatonin to alleviate Jet Lag symptoms and stabilize the Clocks when they are disrupted by Stress or Shift work.

Studies using Zebrafish as a neurological model

Our Team used zebrafish, an outstanding model in neurobiology, and other models to explore sleep. In fact, we were the first ones to characterize sleep in zebrafish, and to discover that melatonin makes them fall asleep faster and sleep longer.

Circadian Clocks, Aging and the Birth of New Neurons

Our Team has explored the role of the circadian clocks in aging, both in humans and in model organisms. Using a zebrafish model we studied the role of Sleep and Clock in the aging process. We were also the first to demonstrate the circadian patterns of neurogenesis in adult brain of day-active animals. Alterations in these patterns are affected by aging, and may underlie or facilitate neurodegenerative disorders.

Selected Reviews and Book chapters on Sleep, Melatonin and Circadian Disorders

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